Joseph Yun, the deputy US assistant secretary for East Asia and Pacific Affairs Bureau, is scheduled to leave on Wednesday for Myanmar, also known as Burma, and stay until May 21, State Department spokesman Mark Toner said.
"Yun will hold introductory meetings with senior government officials in Burma," Toner told reporters, confirming the talks will be the highest since the new government was installed in March.
"He'll also consult a variety of stakeholders, including representatives of political parties, non-governmental organizations, ethnic minorities, as well as the business community," Toner added.
A State Department official said later on condition of anonymity that Yun will also try to meet opposition leader Aung San Suu Kyi, 65, who was released in November after spending most of the past 20 years under house arrest.
Her release came a few days after elections marred by accusations of cheating and intimidation.
In March the military junta made way for a nominally civilian government after almost half a century in power and Than Shwe, the general who ruled Myanmar with an iron fist for 19 years, retired as head of the military.
Last month a friend of Suu Kyi, U Myint, was appointed as an adviser to Myanmar's president.
"I wouldn't read too much into it... that we see any kind of positive signs" from the new government, the anonymous US official said when asked if Yun's visit signaled a change in US diplomacy.
The Obama administration in 2009 launched an engagement drive with Myanmar, concluding that the previous Western policy of trying to isolate the regime had failed.
But the administration has said that it is disappointed with the results of the dialogue and rejected calls by some Asian nations to ease sanctions on Myanmar after the elections.
The United States on Monday renewed its economic sanctions against Myanmar and urged the military-backed regime to go much further after it reduced prisoners' terms by just one year.