The dollar extended its run-up despite disappointing indicators out of Washington on Tuesday, while the euro continues to struggle after eurozone inflation hit a five-year low.
Tokyo edged up 0.26 percent by the break and Sydney edged up marginally 0.31 percent but Seoul was 0.66 percent lower.
Hong Kong and Shanghai were closed for public holidays but markets are keeping a nervous watch on the southern Chinese financial hub as a pro-democracy protest moves into its fourth day.
Following the weekend police tear gassing of demonstrators, there had been fears of clashes as the city's government marked Chinese National Day on Wednesday but by mid-morning there had been no incident.
Protestors, who have shut down some of the city's main thoroughfares, have vowed to stay put until Beijing agrees to give them full universal suffrage.
In Japan the central bank said its closely watched Tankan survey showed confidence among large manufacturers increased to plus 13 in July-September. Markets had forecast a reading of plus 10.
The figure is welcome news for the government after the index tumbled to 12 in April-June following a sales tax hike at the start of the quarter. The index marks the difference between the percentage of firms that are upbeat and those that see conditions as unfavourable.
However, the reading for large non-manufacturing sector firms sank to plus 13 from plus 19.
The greenback gains came despite a rare batch of weak data out of Washington, with the Conference Board index of US consumer confidence falling to 86.0 from 93.4 in August due to concerns about the jobs market.
On Wall Street the Dow eased 0.17 percent, the S&P 500 fell 0.28 percent and the Nasdaq lost 0.28 percent.
In other forex trade the euro bought $1.2610 and 138.64 yen against $1.2631 and 138.50 yen.
On oil markets US benchmark West Texas Intermediate for November delivery was up 36 cents to $91.52 a barrel in mid-morning trade and Brent crude for November advanced 47 cents to $95.14.