Australia made five changes for the game, with India already holding an unbeatable 2-0 lead in the three-match series.
Watson took over the captaincy duties from the injured Aaron Finch (hamstring), with the home side promoting debutants Usman Khawaja and Cameron Bancroft, along with Travis Head, Cameron Boyce and Shaun Tait into the makeshift team.
Dropping out were Finch, spinner Nathan Lyon, Matthew Wade, James Faulkner and John Hastings.
India named an unchanged side, having used the same 11 for all three matches.
Teams:
Australia - Shane Watson (capt), Shaun Marsh, Usman Khawaja, Chris Lynn, Glenn Maxwell, Travis Head, Cameron Bancroft, Cameron Boyce, Scott Boland, Shaun Tait, Andrew Tye
India - Rohit Sharma, Shikhar Dhawan, Virat Kohli, Suresh Raina, Yuvraj Singh, Mahendra Singh Dhoni (capt), Hardik Pandya, Ravindra Jadeja, Ravi Ashwin, Jasprit Bumrah, Ashish Nehra
Umpires: Simon Fry (AUS), John Ward (AUS)
TV Umpire: Paul Wilson (AUS)
Match Referee: Jeff Crowe (NZL)