Two government sources told Reuters they expected Trump to pull the plug at about the same time that negotiators from the United States, Canada and Mexico meet in late January for the sixth round of talks to modernize the North American Free Trade Agreement (NAFTA).
Mexico's peso reversed slight gains against the dollar after the report, and was trading down around 0.4 percent. The S&P/BM IPC stock index was down about 1.8 percent, heading for its biggest loss since Oct. 25.
Trump has repeatedly threatened to walk away from NAFTA, a lynchpin of the Mexican economy, unless Canada and Mexico agree to major changes Washington claims are needed to make the 1994 pact more fair to US workers and businesses.
Yields on short-term Brazilian interest rate futures inched up on Wednesday as higher-than-expected inflation data for 2017 drove traders to trim bets on two additional interest rate cuts.
Price pressures have been muted for months in Brazil, curbed by double-digit unemployment despite an acceleration in economic growth. That may allow the central bank to keep rates at all-time lows for a long time, bolstering the economy's recovery.
The benchmark Bovespa stock index fell 0.84 percent, extending losses for a second day as traders booked profits from a rally early in the year that took it to all-time highs.