Uruguay held a commanding 2-0 halftime lead over World Cup hosts Russia in the battle to top Group A on Monday courtesy of a Luis Suarez free kick and a Denis Cheryshev own goal.
Diego Laxalt's shot came off Russian winger Cheryshev for the own goal and Russia's job got all the harder when Igor Smolnikov was sent off for two yellow cards after 36 minutes.
Both sides have already qualified for the last 16 with two wins.