A protein that appears to be key in the development of Alzheimer's disease has been identified by scientists who say the discovery could provide a new drug target for dementia. Known as GPR3, the protein is believed to play an important role in reducing the build-up of amyloid plaques in the brain, a hallmark of Alzheimer's disease, said the findings in October 14 edition of Science Translational Medicine.
Research on mice with four different varieties of dementia showed that genetically deleting GPR3 resulted in cognitive improvement and reduced signs of disease in the brain.
But since mouse models of Alzheimer's disease are not directly equivalent to the human condition, more research is needed to determine if the same process could work in people.
Researchers are encouraged by the fact that about half of all drugs currently on the market target this type of receptor, known as a G protein-coupled receptor.
Also, autopsies on the brains of people with Alzheimer's have shown that a subset of patients show high levels of GPR3, and that these levels were associated with advancement of the disease.