Manchester City suffered their first defeat under manager Pep Guardiola as Tottenham Hotspur underlined their Premier League title credentials with a 2-0 win at White Hart Lane on Sunday.
Meanwhile reigning champions Leicester City were held to a goalless draw by Southampton while Manchester United endured a frustrating 1-1 draw at home to Stoke City.
An Aleksandar Kolarov own goal and a Dele Alli strike gave Spurs victory and they could even afford for Erik Lamela to squander a second-half penalty.
The result lifted Spurs to second, a point below City.
It was Guardiola's first defeat in 12 games as City manager and followed a mid-week 3-3 draw at Celtic in the Champions League that ended his side's perfect start to the season.
At Old Trafford, it looked as if substitute Anthony Martial's 69th-minute goal would give United victory over a Stoke side who started the day bottom of the table.
But a mistake by United goalkeeper David de Gea led to Joe Allen's equaliser eight minutes from time, the point gained seeing Stoke leapfrog Sunderland.
United wasted numerous chances, with world-record signing Paul Pogba and Zlatan Ibrahimovic among the offenders as Stoke goalkeeper Lee Grant, on loan from Derby County, made several fine saves.
Elsewhere, strikers Jamie Vardy of Leicester and Charlie Austin of Southampton both missed chances in a drab goalless stalemate at the King Power Stadium.
The draw left Leicester marooned in mid-table, with hopes of a successful title defence fading fast.