American John Isner became the latest seed to be upset at the ATP Tour's Memphis Open on Friday as the second seed lost in three sets to unheralded Donald Young. The world No. 81 Young posted his first career win over Isner in four meetings by outlasting the fellow American 7-6 (7/5), 3-6, 7-6 (8/6) to reach the semi-finals. Isner was the last remaining seed in the tournament as none of the top seeds reached the semis. Qualifier Mikhail Kukushkin powered his way into the semi-finals with a 6-0, 6-4 victory over fourth-seeded Steve Johnson. Basilashvili, of Georgia, advanced to the quarter-finals by knocking off top-seeded Ivo Karlovic on Thursday.