The real lost 0.4 percent, while Mexico's peso sipped 0.2 percent. The greenback strengthened as upbeat economic data from the United States assuaged fears of a slowdown in global growth.

Chile's peso, which had surged 1.7 percent last session, fell 0.3 percent as prices of copper - the country's main export - fell.

Regional stocks underperformed their broader emerging market peers as a decline on Wall Street after a three days of gains put a damper on sentiment.

Upbeat manufacturing data from the United States and China had supported risk sentiment earlier in the global day, helping the broader emerging market shares index extend its rally to a fourth session.

Regionally, Brazil's main stock index gave up early gains of as much as 0.7 percent, to trade flat as gains in material and consumer staples were offset by losses in financials.

Brewer Ambev was the biggest boost, up 1.3 percent, while iron ore miner Vale climbed as prices of the steel-making ingredient hit all-time highs.

Lenders were the biggest drags, with Banco Bradesco and Itau Unibanco losing 1.2 percent ad 0.6 percent, respectively.

In the latest on the progress of much awaited pension reforms, Brazil's Vice President Hamilton Mourao said he expects Congress to approve the reform in coming months, and that next up will be tax reform.

Stocks in Chile fell half a percent, on-track to post its biggest one-day fall in more than a week, while Colombian equities declined for a second day.