At 0728 GMT, the pan-European STOXX 600 index dipped 0.07 percent, with Paris's CAC down 0.2 percent and Frankfurt's trade-sensitive DAX off 0.1 percent.
Shares of planemaker Airbus dropped 2.5 percent after the U.S. Trade Representative proposed tariffs on a list of European Union products including large commercial aircraft and parts. Washington is seeking to retaliate for more than $11 billion worth of EU subsidies to Airbus that the World Trade Organization has found cause "adverse effects" for the United States.
Airbus suppliers such as Safran, Leonardo and Dassault lost between 0.7 percent and 1.2 percent.
Investors are also keeping a close eye on a trade summit between the European Union and China on Tuesday in which the bloc will try to coax Beijing to open up its markets.
The European Central Bank is expected to hold borrowing costs when its policymakers meet on Wednesday, the same day British Prime Minister Theresa May's request to delay Brexit until June 30 will be formally discussed by EU leaders at a special summit.
Swiss drugmaker Novartis slipped over 2 percent, among the biggest drags on STOXX 600, trading for the first day after completing the spin off its eyecare division Alcon .
Alcon shares surged 32 percent in its debut.
Bechtle AG dropped more than 2 percent and pulled the tech sector lower after Berenberg downgraded the German IT company's stock to "hold".
Merck KGaA dipped on winning the backing of Versum's board for a sweetened $6.5 billion takeover bid, overturning an agreed merger with rival Entegris as it bets on a recovery in electronic materials markets.
Norwegian mobile operator Telenor slipped after agreeing to buy a 54 percent stake in Finnish telecoms firm DNA for 1.5 billion euros ($1.69 billion).
Keeping losses in check were shares of Total SA, which rose after the French oil and gas major and its partners signed a long-awaited deal with Papua New Guinea that will allow initial work to start on a $13 billion plan to double the country's liquefied natural gas exports.