At 1537 GMT, the rand traded at 14.3100 per dollar, 1.01 percent weaker than its New York close on Monday.
The greenback climbed across the board on Tuesday as financial markets re-opened after the Easter holiday and traders favoured the dollar ahead of the release on Friday of US gross domestic product data for the first three months of 2019.
In the absence of local market moving data, the rand is expected to track global market sentiment this week, even though South African-focused investors were keeping an eye on election news ahead of parliamentary and provincial votes on May 8.
"We might well begin to see a domestic risk premium being applied to rand assets as the polls draw near, with investors becoming more sensitive to local news flow, particularly relating to social unrest," RMB analyst Nema Ramkhelawan-Bhana said in a note.
Globally, markets are looking to the release of the US GDP data for indications about the strength of the world's largest economy.
Better-than-expected economic readings from both the United States and China lately have assuaged investor concerns of a sharp global economic slowdown, although weak manufacturing surveys from Asia and Europe have kept a lid on sentiment.
In fixed income, the yield on the benchmark government bond due in 2026, added 8.5 basis points to close at 8.55 percent.
On the bourse, stocks rose following positive news in the energy sector, with the Top40-index up by 0.59 percent to 53,184.19 points while the broader All-Share index rose by 0.54 percent to 59,544.80 points.
Chemicals and fertiliser company Omnia Holdings was the top performer on the blue-chip index, rising by 16.28 percent to 58.14 rand after it said it would be working towards a collaborative debt restructuring plan alongside its principal debt providers.
Sasol Ltd climbed 4.21 percent to 487.49 rand after oil prices jumped to near six-month highs on Tuesday, as the United States tightened sanctions on Iran.
News on the operation of its new alkoxylation plant, which was completed within the expected time frame and allocated budget, also boosted Sasol.
On the downside, gold mining stocks dropped 2.4 percent as gold prices slipped as the dollar gained and investors preferred riskier assets, dampening the safe-haven metal's appeal.