At peaks in the previous session Europe's pan-regional STOXX 600 index had gained 4.5pc this month, undoing most of a sell-off in May that was its worst monthly performance in more than two years.
That came largely courtesy of signs that the US Federal Reserve and European Central Bank will take action to stem any slowdown in global growth due to the erecting of tariff barriers between some of the world's biggest economies.
President Donald Trump said on Tuesday he would hold up a trade deal with China unless it agrees to four or five major points, reheating tensions between the two sides.
The STOXX 600 fell 0.44pc by 0816 GMT, tracking Asian markets lower, with the tariff-sensitive technology sector down 0.76pc.
"The markets ... had a very strong start to the month, there is no real reason for them to keep going at the moment," said Connor Campbell, an analyst at Spreadex in London, pointing to US inflation numbers later in the day as the next possible driver.
Also pressuring the tech sector was an almost 1pc drop for Dassault Systemes' after the French technology company agreed to buy US software firm Medidata Solutions in a deal worth $5.8 billion.
Chipmakers, which get a huge portion of their revenue from China, fell, with AMS AG and STMicroelectronics declining about 0.5pc.
With under three weeks to go before proposed talks between US and China, expectations for progress toward ending the trade war are low and sources say there has been little preparation for a meeting even as the health of the world economy is at stake.
Trump also said that interest rates were "way too high", ahead of a reading on US inflation that could shift the odds towards a cut in rates as soon as July.
Banking stocks, which tend to suffer when expectations for interest rates fall, lost 0.81pc, taking the biggest hit among the major European sectors.
Italy's FTSE MIB fell 0.81pc and its banking index dropped 1.28pc as the European Union moved closer to taking disciplinary action over the country's growing debt.
Axel Springer jumped 12.3pc after funds controlled by US private equity investor KKR offered to buy out minority shareholders of the German publisher for 63 euros a share, a 40pc premium to its market price.
British American Tobacco fell 3pc after four straight sessions of gains and weighed on the STOXX 600, despite forecasting sales of vaping and e-cigarette products would accelerate in the second half of the year.