The main index and the mid-cap FTSE 250 edged 0.2% lower by 0715 GMT, with global markets continuing to scale back bets of a hefty rate cut by the U.S. central bank.
Miners were among the biggest drags on the blue-chip index as copper prices continued their recent slide on worries over waning demand from top consumer China.
Ocado added 3.7% after the company backed its annual forecast, even though its first-half core earnings nearly halved, partly due to the impact of a fire at its flagship robotic warehouse in February.
Micro Focus gave up 2.9% after posting lower half-year revenue.