European shares were little changed on Friday as drugmakers came under pressure on worries the US government may intervene over high drug prices, while Federal Reserve chairman Jerome Powell's dovish comments helped limit losses.

The pan-European STOXX 600 index ended flat but broke a five-week winning streak as regional equities failed to take advantage of the Fed's accommodative stance this week.

Swiss stocks underperformed, sliding more than 1% as drugmakers including Roche Holdings, Novartis and Novo Nordisk fell more than 2%.

European drugmakers have weighed on the healthcare index since Thursday after the White House scrapped an ambitious health rebate plan and raised the possibility of US lawmakers intervening on high drug prices.

Auto stocks recovered from the previous session to close nearly 1% higher, although Daimler underperformed after the world's largest truckmaker warned investors it expected to swing to a second-quarter loss.

"It's highly indicative of what is happening on trade over the last couple of months," said Stefan Koopman, senior market economist at Rabobank in Utrecht, Netherlands.

"We've seen carmakers have difficulty, with Chinese car sales dropping over the past 6 to 12 months."

Chemicals made the biggest gains with Swiss specialist EMS-Chemie closing 5% higher on good first-half results. However, it warned that the trade conflict between major powers caused considerable uncertainty among consumers and companies.

The warning came days after German chemical giant BASF highlighted the repercussions of the protracted trade war between the United States and China, especially the toll it was likely to take on the agricultural and auto sectors.

In contrast to world stocks, European shares had a tepid week, although they have regained their footing after a huge sell-off in May due to an escalation in US-China trade tensions and expectations of rate cuts by major central banks.

Volumes on the STOXX 600 index were well-below long-term averages on Friday as investors braced for next week's earnings deluge.

Europe's most valuable technology company, SAP, semiconductor company ASML and Novartis are among those due to report second-quarter results next week.

Companies listed on the pan-European STOXX 600 index are expected to report 0.8% earnings growth in the second quarter, down sharply from an estimate of 1.8% a week ago, according to data from I/B/E/S Refinitiv on Tuesday.