The layoffs are expected to affect jobs at Huawei's US-based research and development subsidiary Futurewei Technologies, which employs about 850 people in research labs across the United States, the Journal said.
The layoffs could be in the hundreds, one person told the Journal. Huawei's Chinese employees in the United States were being given an option to return home and stay with the company, another person added.
Some employees have already been notified of their dismissal, while more planned job cuts could be announced soon, the newspaper said.
Huawei declined to comment when contacted by Reuters.
After the Commerce Department decided to put Huawei on its so-called entity list, Futurewei employees have faced restrictions to communicate with their colleagues in Huawei's home offices located in China, the people told the Journal.
Last week, Commerce Secretary Wilbur Ross said the US government would issue licenses to companies seeking to sell goods to Huawei where there was no threat to national security.