Top seed Djokovic, who saved two match points in the All England Club final to deny Federer a record ninth title at the grasscourt championships, will start his campaign against 76th-ranked Roberto Carballes Baena before facing a potential second-round showdown against American Sam Querrey.

Third seed Federer, who won the last of his five Flushing Meadows trophies in 2008, will open against a qualifier as he chases a 21st Grand Slam title.

Second seed Rafael Nadal, who was beaten by Federer in the Wimbledon semi-finals, will play Australian John Millman in the first round of the hardcourt major which starts on Monday. Millman reached the US Open quarter-finals last year after knocking out Federer in the last 16.

The Spaniard, three-times a champion in New York, could run into 2014 champion Marin Cilic in the fourth round.