"This is the book that the leftist elites don't want you to read!" screams a blurb on Amazon, adding that "no topic is spared from political correctness."
Trump Jr. dedicates the 300-page part memoir to "deplorables," a clear dig at Clinton who used the term to describe Trump supporters during the 2016 presidential campaign.
The book quickly rose to third on Amazon's list of bestselling books after the president on Monday encouraged his 66.5 million Twitter followers to order a copy.
"A great new book that I highly recommend for ALL to read," Trump tweeted.
Trump Jr, known for his virulent attacks on traditional media including The New York Times and the Washington Post, accuses social networks of trying to sensor him and other conservatives.