The main index shed 0.6pc, with HSBC dragging a sub-index of banks 2.5pc lower after its annual profit declined and it laid out plans for a major strategic overhaul that included 35,000 job cuts and the halting of share buybacks.
"We are concerned by the precedent perhaps being set by HSBC of suspending buybacks, a big source of upward pressure on stock prices," London Capital Group analyst Jasper Lawler said.
The more domestically-focussed FTSE 250 also gave up 0.3pc but still fared better than its blue-chip counterpart, which was hurt more due to a larger exposure to commodity prices which are under pressure over concerns of demand.
Global market participants poured money into perceived safe havens including gold after the signals from Apple, the world's most valuable technology firm, that sales would be hurt by the outbreak.
That underlined the economic impact of the outbreak, which has begun to emerge in more concrete financial declarations from companies in the past few days.
Holiday Inn-owner InterContinental Hotels also dipped as much as 2pc after it said it would take a hit from the virus and reported a fall in revenue per room due to the impact of the past year's protests in Hong Kong.
AIM-listed engineering firm Tekmar sank 34pc after it warned results would now be worse than previously thought thanks to a halt in shipments to and from China.
On the back of Apple's statement, Europe's index of tech stocks fell 1.5pc.
"When the world's largest company sneezes, everyone else is likely to catch a cold," OANDA analyst Jeffrey Halley said.
The losses followed modest rises in the previous session when China introduced more stimulus measures to shore up its economy and as many investors were away due to a U.S. holiday.
Utilities Severn Trent and United Utilities outperformed the broader market, climbing about 2pc each after JPMorgan sounded bullish on the sector following a recent price control published by Britain's water regulator.
NMC Health advanced for the second straight session climbing 8pc, a day after its founder BR Shetty resigned as co-chairman of the healthcare company amid doubts about the shareholdings of its major investors.
The company is still worth less than half of what it was three months ago.