Two US drones fired four missiles at a house belonging to a militant commander in Wacha Dana town, 10 kilometres (six miles) west of Wana, the main town in the South Waziristan, security officials said.

"At least five militants have died. The house has been badly destroyed," a security official told AFP, on condition of anonymity.

Two other security officials confirmed the strikes. One intelligence officer put the toll at six dead.

Sunday's attack in South Waziristan was the second in as many days and follows a surge in drone strikes in Pakistan since a NATO conference on Afghanistan in Chicago last month.