People with clinical depression may be unable to "snap out of it" because of faulty wiring in the brain, according to a study released on August 15.
Researchers who compared the way people with very severe depression responded to negative stimuli relative to a group of healthy controls found that the circuits involved in controlling emotions were disrupted in the depressed individuals.
"The neural circuits involved with regulating emotions may be damaged in people with this condition," said Tom Johnstone, a neuroscientist at the University of Wisconsin-Madison's School of Medicine and Public Health and lead author of the study published in the journal Neuroscience.
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