Inhalers may raise risk of asthma

Common asthma reliever drugs taken by millions of children around the world may increase the risk of asthma attacks in some patients with a particular genetic make-up, British scientists said.
The researchers found that salbutamol, a popular blue inhaler medicine also known as Ventolin, as well as salmeterol, an ingredient in GlaxoSmithKline's Advair, are less effective in children with a specific gene variant and may in some cases make their asthma worse.
The scientists said their findings suggest that carrying out genetic tests on children before treatment could be a more cost-effective way of treating them. "This is a global question that needs to be addressed," said Somnath Mukhopadhyay of Brighton and Sussex Medical School.
Salbutamol is called albuterol in the United States and is very widely used, the researchers told a news conference. US drug regulators have cautioned in the past that asthma drugs like Advair and Serevent, also made by Glaxo, may actually increase asthma risk in some patients. Glaxo said in a statement it had carried out its own studies with Advair and Serevent and found no genetic variation response differences, although the 500 patients in its study were older than 12.
"Albuterol is one of the commonest drugs right across the world. It is used in the United States, in Africa, India" said Mukhopadhyay. "It's cheap, it's popular, and it'ss good stuff - when it works. Asthma affects more than 300 million people world-wide and is the most common children's chronic illness. Symptoms include wheezing, shortness of breath, coughing and chest tightness.
The British study, which looked at patients aged between 3 and 22 years, showed that asthma patients using their inhaler on a daily basis who carry a gene variant called Arg16 had a 30 percent greater risk of asthma attacks compared with those with the more usual form of the gene. Those with two copies of the gene showed a 70 percent increase of asthma attacks, but the scientists noted that children taking daily doses were those with more severe asthma.