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Two US companies this year broke new ground by winning regulatory approval to start the first experiments using embryonic stem cells on humans suffering from spinal cord injury and blindness. The potent but hotly debated cells can transform into nearly any cell in the human body, opening a path toward eliminating such ills as Parkinson's disease, paralysis, diabetes, heart disease, and maybe even the ravages of aging.
And more human experiments are on the way as scientists refine new methods to get around the controversy that surrounds embryonic stem cell research, which involves the destruction of early human life. "After a decade of intense controversy, the field is finally ready to start proving itself and to actually start helping patients suffering from a range of horrific diseases," said Bob Lanza, chief scientist at Advanced Cell Technology.
His company was cleared in November by the US Food and Drug Administration to begin testing a therapy derived from embryonic stem cells to treat a rare form of blindness that strikes in childhood, known as Stargardt's disease. Clinical trials are expected to start in the coming months, and results could be known within six weeks.
In October, Geron Corporation announced it had begun the first-ever test of human embryonic stem cells in a patient suffering from spinal cord injury. In all about a dozen patients are expected to participate in the year-long study. The primary aim of both ACT's and Geron's studies is to gauge safety, not necessarily to restore mobility or vision.
The major concern with stem cell therapies is that the transforming cells could form tumors. But if the methods appear safe, both companies aim to expand their trials to wider populations in the hopes of eventually curing paralysis and blindness.
Twelve years ago, American scientist James Thomson's team isolated human embryonic stem cells for the first time, and the field has been cloaked in controversy ever since. Former president George W. Bush outlawed federal funding for the research because it involves the disposal of human embryos, a ban that President Barack Obama reversed shortly after taking office in 2009.
But in August of this year, Judge Royce Lamberth blocked US government funding for embryonic stem cell research after ruling in favour of a coalition of groups, including several Christian organisations. While the funding has since been permitted to go ahead pending appeal, the legal wrangling has left some scientists wary of the future.
"The on-again-off-again situation will only stall the progress of everyone's work," said Tim Kamp, head of the University of Wisconsin's Stem Cell and Regenerative Medicine Center, back in September. To get around the problems associated with embryonic stem cell research, scientists in 2010 forged new paths toward creating induced pluripotent cells, which can transform into skin, blood or heart cells. Embryonic stem cells are pluripotent cells.
The field of induced pluripotent cells (iPS) faces its own challenges, as studies have shown they are less efficient and more unpredictable than embryonic cells. And a Harvard University scientist, Derrick Rossi, discovered a way to avoid risky genetic modification and instead use RNA molecules to reprogram adult human cells into pluripotent cells without altering the DNA.

Copyright Agence France-Presse, 2011

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