Karatsev became the first man in the open era to reach the semi-finals on his Grand Slam debut and the lowest-ranked player to reach the last four of a major for two decades.
"It gives me more experience, more confidence," Karatsev told reporters after his 6-3 6-4 6-2 defeat. "Now I will be playing all big tournaments without playing the qualifiers.
The surprise of the men's draw has been Russian qualifier Aslan Karatsev, who will be looking for a semi-final place in his first Grand Slam tournament when he faces Bulgaria's 18th seed Grigor Dimitrov.