Saqib Mahmood, Lewis Gregory and Matt Parkinson have all been included in a 16-man squad after starring in the ODIs, with T20 regular Dawid Malan keeping his place.
Jos Buttler has also been included following a calf injury.
A new England XI thrashed Pakistan to take unassailable 2-0 lead in ODI series
World Cup-winning skipper Morgan and all of England's originally-selected squad for this three-match campaign had to self-isolate after three players and four support staff tested positive for Covid-19