"In any case, it won't be this government that reforms the justice and tax system," Salvini told La Repubblica daily, saying centre-left parties within the broad-based cabinet had very different views to their centre-right counterparts.
The EU money will only be released in tranches, meaning the taps could be closed if the reforms fail to materialise.
Draghi told the lower house of parliament he shared the aim behind US President Joe Biden's call for a waiver of patents on coronavirus vaccines, adding that a temporary suspension would probably not discourage pharmaceutical research.
"I will propose to parliament ... a new increase in the deficit," said Draghi, who took office a month ago at the head of a government of national unity. Rome's most recent estimate was for a deficit-to-GDP ratio of 8.8% this year.