Two other Alien CryptoPunk NFTs have sold for more than $7 million each in previous sales. Anyone can view the artworks the NFTs represent, but only the buyer has the official status of being the owner.
The match between Cristiano Ronaldo's Juventus and Atalanta is due to take place on May 19.
"We are the first football league in the world to sign an agreement in this new market which is extremely innovative and relevant," said Luigi De Siervo, chief executive of Serie A.