"Economic recovery must go hand in hand with an improved health situation on the ground. I welcome Portugal's recovery and resilience plan as the first one officially submitted to the Commission," she said in a statement.
Several European diplomats in Brussels said the commission president's widely reported tendency to rely on a small number of trusted aides had let her down in such a complex crisis.
"BioNTech/Pfizer will deliver 75 million of additional doses in the second quarter of the year - and up to 600 millions in total in 2021," von der Leyen wrote on Twitter.
The European Parliament has demanded that it see the text of any accord by Sunday at the latest, and the UK government says it will not allow talks to go beyond December 31.