Jabeur dipped into her box of tricks to outflank the powerful 11th seed who was slowly driven to distraction by an opponent who gave a masterclass in angles and spins.
"I would have dearly wished, and I gave everything again, that there would have been 109 internationals in the end and that this one big title, the European Championship, would have been added at the end."
Sabalenka, who had been given a scare by lowly ranked Briton Katie Boulter in the previous round, romped to the first set and looked set to wrap up victory with her opponent winning just a solitary game.
Former world number one Pliskova fell at first hurdle in the tune-up tournaments in Berlin and Eastbourne last month but the 29-year-old has yet to drop a set at Wimbledon.