Kerber faced a tough test against Sara Sorribes Tormo in the previous round before overcoming the Spaniard in the longest women's match at Wimbledon since 2011 and made a sluggish start on Saturday by twice dropping serve in the opening set to give Sasnovich a 4-0 lead.
The 25-year-old Italian put his booming serve and crunching forehand to good use against the 64th-ranked Bedene whom he defeated in four sets on his way to the second week of the grasscourt Grand Slam in 2019.
Gauff, the 23rd seed, stormed through the opening games with a barrage of power serves on Centre Court but was asked some awkward questions by 102nd-ranked Juvan.
Pacquiao on Thursday accepted Philippine President Rodrigo Duterte's challenge to show evidence of corruption in his government, and the boxing superstar said his findings about missing funds were the tip of the iceberg.